Archive for January, 2022
Trim, Red, Softail..
Monday, January 31st, 2022Goofy, Fat tired, Shovelhead..
Monday, January 31st, 2022King and Queen on a Panhead.
Monday, January 31st, 2022Low Down Panhead..
Monday, January 31st, 2022David Mann..
Saturday, January 29th, 2022Generator Shovel.
Saturday, January 29th, 2022Asian Toy Land..
Saturday, January 29th, 2022Too nice to change..
Saturday, January 29th, 2022Twice Piped Pan..
Saturday, January 29th, 2022Ice Man…….
Saturday, January 29th, 2022Low Down Shovelhead
Saturday, January 29th, 2022Good Morning Sports Fans..
Saturday, January 29th, 2022Purple Pan..
Saturday, January 29th, 2022Blue, Rigid, Shovelhead.
Friday, January 28th, 2022Sportster.
Friday, January 28th, 2022My dentist used an Ivermectin tablet from Mexico and his Rona symptoms disappeared after 6 hours. The first hour he felt twitchy. He is approx. 40 years of age and in general good health. This is a controlled substance. I am posting this story because it needs to be told.. Use good sense and discuss with your doctor. The push to vaccinate is based on what the Government has decided. You may chose what is best for you, if you dare.
Friday, January 28th, 2022American Journal of TherapeuticsAm J Ther. 2021 Jul-Aug; 28(4): e434–e460.Published online 2021 Jun 21. doi: 10.1097/MJT.0000000000001402PMCID: PMC8248252PMID: 34145166
Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines
Andrew Bryant, MSc,1,*Theresa A. Lawrie, MBBCh, PhD,2Therese Dowswell, PhD,2Edmund J. Fordham, PhD,2Scott Mitchell, MBChB, MRCS,3Sarah R. Hill, PhD,1 and Tony C. Tham, MD, FRCP4Author informationCopyright and License informationDisclaimerThis article has been cited by other articles in PMC.Go to:
Background:
Repurposed medicines may have a role against the SARS-CoV-2 virus. The antiparasitic ivermectin, with antiviral and anti-inflammatory properties, has now been tested in numerous clinical trials.
Areas of uncertainty:
We assessed the efficacy of ivermectin treatment in reducing mortality, in secondary outcomes, and in chemoprophylaxis, among people with, or at high risk of, COVID-19 infection.
Data sources:
We searched bibliographic databases up to April 25, 2021. Two review authors sifted for studies, extracted data, and assessed risk of bias. Meta-analyses were conducted and certainty of the evidence was assessed using the GRADE approach and additionally in trial sequential analyses for mortality. Twenty-four randomized controlled trials involving 3406 participants met review inclusion.
Therapeutic Advances:
Meta-analysis of 15 trials found that ivermectin reduced risk of death compared with no ivermectin (average risk ratio 0.38, 95% confidence interval 0.19–0.73; n = 2438; I2 = 49%; moderate-certainty evidence). This result was confirmed in a trial sequential analysis using the same DerSimonian–Laird method that underpinned the unadjusted analysis. This was also robust against a trial sequential analysis using the Biggerstaff–Tweedie method. Low-certainty evidence found that ivermectin prophylaxis reduced COVID-19 infection by an average 86% (95% confidence interval 79%–91%). Secondary outcomes provided less certain evidence. Low-certainty evidence suggested that there may be no benefit with ivermectin for “need for mechanical ventilation,” whereas effect estimates for “improvement” and “deterioration” clearly favored ivermectin use. Severe adverse events were rare among treatment trials and evidence of no difference was assessed as low certainty. Evidence on other secondary outcomes was very low certainty.
Conclusions:
Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. Using ivermectin early in the clinical course may reduce numbers progressing to severe disease. The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally.